SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
Identifieur interne : 000050 ( Main/Exploration ); précédent : 000049; suivant : 000051SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
Auteurs : Takuo Yamai [Japon] ; Hayato Hikita [Japon] ; Makoto Fukuoka [Japon] ; Keisuke Fukutomi [Japon] ; Kazuhiro Murai [Japon] ; Tasuku Nakabori [Japon] ; Ryoko Yamada [Japon] ; Kei Miyakawa [Japon] ; Kohei Watashi [Japon] ; Akihide Ryo [Japon] ; Takahiro Kodama [Japon] ; Ryotaro Sakamori [Japon] ; Tomohide Tatsumi [Japon] ; Tetsuo Takehara [Japon]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2020.
Abstract
Autophagy is an intracellular process that can lead to the degradation of malfunctioned proteins and damaged organelles to maintain homeostasis during cellular stress. Here, we evaluated the change in hepatitis B virus (HBV) production by regulating hepatic autophagy in HBV-producing cells. We examined focusing on a relation with a positive autophagy regulator, sirtuin1 (SIRT1). Starvation and rapamycin treatment induced autophagy with increasing SIRT1 protein, HBc protein and pregenomic RNA (pgRNA) levels in HBV- producing cells. Knockdown of Atg7 or Atg13 suppressed hepatic autophagy, and it did not change SIRT1 protein, HBc protein or pgRNA levels in HBV- producing cells. Resveratrol, which increases SIRT1 expression and activity, promoted autophagy and increased HBc protein and pgRNA levels. siRNA-mediated knockdown of SIRT1 inhibited autophagy and decreased HBc protein and pgRNA levels. In SIRT1-knockdown cells, starvation promoted autophagy but did not increase HBc protein and pgRNA levels. In conclusion, HBc protein and pgRNA levels are upregulated not by the autophagic process itself but by the SIRT1 expression level.
DOI: 10.1016/j.bbrc.2020.04.031
PubMed: 32446392
Affiliations:
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Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Murai, Kazuhiro" sort="Murai, Kazuhiro" uniqKey="Murai K" first="Kazuhiro" last="Murai">Kazuhiro Murai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Nakabori, Tasuku" sort="Nakabori, Tasuku" uniqKey="Nakabori T" first="Tasuku" last="Nakabori">Tasuku 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sort="Miyakawa, Kei" uniqKey="Miyakawa K" first="Kei" last="Miyakawa">Kei Miyakawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Yokohama City University School of Medicine, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Watashi, Kohei" sort="Watashi, Kohei" uniqKey="Watashi K" first="Kohei" last="Watashi">Kohei Watashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640</wicri:regionArea><wicri:noRegion>162-8640</wicri:noRegion></affiliation></author><author><name sortKey="Ryo, Akihide" sort="Ryo, Akihide" uniqKey="Ryo A" first="Akihide" last="Ryo">Akihide Ryo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Yokohama City University School of Medicine, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Kodama, Takahiro" sort="Kodama, Takahiro" uniqKey="Kodama T" first="Takahiro" last="Kodama">Takahiro Kodama</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Sakamori, Ryotaro" sort="Sakamori, Ryotaro" uniqKey="Sakamori R" first="Ryotaro" last="Sakamori">Ryotaro Sakamori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Tatsumi, Tomohide" sort="Tatsumi, Tomohide" uniqKey="Tatsumi T" first="Tomohide" last="Tatsumi">Tomohide Tatsumi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Takehara, Tetsuo" sort="Takehara, Tetsuo" uniqKey="Takehara T" first="Tetsuo" last="Takehara">Tetsuo Takehara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan. Electronic address: takehara@gh.med.osaka-u.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32446392</idno><idno type="pmid">32446392</idno><idno type="doi">10.1016/j.bbrc.2020.04.031</idno><idno type="wicri:Area/Main/Corpus">000070</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000070</idno><idno type="wicri:Area/Main/Curation">000070</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000070</idno><idno type="wicri:Area/Main/Exploration">000070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.</title><author><name sortKey="Yamai, Takuo" sort="Yamai, Takuo" uniqKey="Yamai T" first="Takuo" last="Yamai">Takuo Yamai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Hikita, Hayato" sort="Hikita, Hayato" uniqKey="Hikita H" first="Hayato" last="Hikita">Hayato Hikita</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Fukuoka, Makoto" sort="Fukuoka, Makoto" uniqKey="Fukuoka M" first="Makoto" last="Fukuoka">Makoto Fukuoka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Fukutomi, Keisuke" sort="Fukutomi, Keisuke" uniqKey="Fukutomi K" first="Keisuke" last="Fukutomi">Keisuke Fukutomi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Murai, Kazuhiro" sort="Murai, Kazuhiro" uniqKey="Murai K" first="Kazuhiro" last="Murai">Kazuhiro Murai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Nakabori, Tasuku" sort="Nakabori, Tasuku" uniqKey="Nakabori T" first="Tasuku" last="Nakabori">Tasuku Nakabori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, Ryoko" sort="Yamada, Ryoko" uniqKey="Yamada R" first="Ryoko" last="Yamada">Ryoko Yamada</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Miyakawa, Kei" sort="Miyakawa, Kei" uniqKey="Miyakawa K" first="Kei" last="Miyakawa">Kei Miyakawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Yokohama City University School of Medicine, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Watashi, Kohei" sort="Watashi, Kohei" uniqKey="Watashi K" first="Kohei" last="Watashi">Kohei Watashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640</wicri:regionArea><wicri:noRegion>162-8640</wicri:noRegion></affiliation></author><author><name sortKey="Ryo, Akihide" sort="Ryo, Akihide" uniqKey="Ryo A" first="Akihide" last="Ryo">Akihide Ryo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Yokohama City University School of Medicine, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Kodama, Takahiro" sort="Kodama, Takahiro" uniqKey="Kodama T" first="Takahiro" last="Kodama">Takahiro Kodama</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Sakamori, Ryotaro" sort="Sakamori, Ryotaro" uniqKey="Sakamori R" first="Ryotaro" last="Sakamori">Ryotaro Sakamori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Tatsumi, Tomohide" sort="Tatsumi, Tomohide" uniqKey="Tatsumi T" first="Tomohide" last="Tatsumi">Tomohide Tatsumi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Takehara, Tetsuo" sort="Takehara, Tetsuo" uniqKey="Takehara T" first="Tetsuo" last="Takehara">Tetsuo Takehara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan. Electronic address: takehara@gh.med.osaka-u.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is an intracellular process that can lead to the degradation of malfunctioned proteins and damaged organelles to maintain homeostasis during cellular stress. Here, we evaluated the change in hepatitis B virus (HBV) production by regulating hepatic autophagy in HBV-producing cells. We examined focusing on a relation with a positive autophagy regulator, sirtuin1 (SIRT1). Starvation and rapamycin treatment induced autophagy with increasing SIRT1 protein, HBc protein and pregenomic RNA (pgRNA) levels in HBV- producing cells. Knockdown of Atg7 or Atg13 suppressed hepatic autophagy, and it did not change SIRT1 protein, HBc protein or pgRNA levels in HBV- producing cells. Resveratrol, which increases SIRT1 expression and activity, promoted autophagy and increased HBc protein and pgRNA levels. siRNA-mediated knockdown of SIRT1 inhibited autophagy and decreased HBc protein and pgRNA levels. In SIRT1-knockdown cells, starvation promoted autophagy but did not increase HBc protein and pgRNA levels. In conclusion, HBc protein and pgRNA levels are upregulated not by the autophagic process itself but by the SIRT1 expression level.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32446392</PMID><DateRevised><Year>2020</Year><Month>05</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>527</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jun</Month><Day>18</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.</ArticleTitle><Pagination><MedlinePgn>64-70</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(20)30755-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2020.04.031</ELocationID><Abstract><AbstractText>Autophagy is an intracellular process that can lead to the degradation of malfunctioned proteins and damaged organelles to maintain homeostasis during cellular stress. Here, we evaluated the change in hepatitis B virus (HBV) production by regulating hepatic autophagy in HBV-producing cells. We examined focusing on a relation with a positive autophagy regulator, sirtuin1 (SIRT1). Starvation and rapamycin treatment induced autophagy with increasing SIRT1 protein, HBc protein and pregenomic RNA (pgRNA) levels in HBV- producing cells. Knockdown of Atg7 or Atg13 suppressed hepatic autophagy, and it did not change SIRT1 protein, HBc protein or pgRNA levels in HBV- producing cells. Resveratrol, which increases SIRT1 expression and activity, promoted autophagy and increased HBc protein and pgRNA levels. siRNA-mediated knockdown of SIRT1 inhibited autophagy and decreased HBc protein and pgRNA levels. In SIRT1-knockdown cells, starvation promoted autophagy but did not increase HBc protein and pgRNA levels. In conclusion, HBc protein and pgRNA levels are upregulated not by the autophagic process itself but by the SIRT1 expression level.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yamai</LastName><ForeName>Takuo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hikita</LastName><ForeName>Hayato</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fukuoka</LastName><ForeName>Makoto</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fukutomi</LastName><ForeName>Keisuke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murai</LastName><ForeName>Kazuhiro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakabori</LastName><ForeName>Tasuku</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamada</LastName><ForeName>Ryoko</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyakawa</LastName><ForeName>Kei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watashi</LastName><ForeName>Kohei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryo</LastName><ForeName>Akihide</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kodama</LastName><ForeName>Takahiro</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakamori</LastName><ForeName>Ryotaro</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tatsumi</LastName><ForeName>Tomohide</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takehara</LastName><ForeName>Tetsuo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan. Electronic address: takehara@gh.med.osaka-u.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">HBV</Keyword><Keyword MajorTopicYN="N">Replication</Keyword><Keyword MajorTopicYN="N">Sirtuin1 (SIRT1)</Keyword><Keyword MajorTopicYN="N">Transcription</Keyword></KeywordList><CoiStatement>Declaration of competing interest All authors have no competing financial interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32446392</ArticleId><ArticleId IdType="pii">S0006-291X(20)30755-5</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2020.04.031</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Yamai, Takuo" sort="Yamai, Takuo" uniqKey="Yamai T" first="Takuo" last="Yamai">Takuo Yamai</name></noRegion><name sortKey="Fukuoka, Makoto" sort="Fukuoka, Makoto" uniqKey="Fukuoka M" first="Makoto" last="Fukuoka">Makoto Fukuoka</name><name sortKey="Fukutomi, Keisuke" sort="Fukutomi, Keisuke" uniqKey="Fukutomi K" first="Keisuke" last="Fukutomi">Keisuke Fukutomi</name><name sortKey="Hikita, Hayato" sort="Hikita, Hayato" uniqKey="Hikita H" first="Hayato" last="Hikita">Hayato Hikita</name><name sortKey="Kodama, Takahiro" sort="Kodama, Takahiro" uniqKey="Kodama T" first="Takahiro" last="Kodama">Takahiro Kodama</name><name sortKey="Miyakawa, Kei" sort="Miyakawa, Kei" uniqKey="Miyakawa K" first="Kei" last="Miyakawa">Kei Miyakawa</name><name sortKey="Murai, Kazuhiro" sort="Murai, Kazuhiro" uniqKey="Murai K" first="Kazuhiro" last="Murai">Kazuhiro Murai</name><name sortKey="Nakabori, Tasuku" sort="Nakabori, Tasuku" uniqKey="Nakabori T" first="Tasuku" last="Nakabori">Tasuku Nakabori</name><name sortKey="Ryo, Akihide" sort="Ryo, Akihide" uniqKey="Ryo A" first="Akihide" last="Ryo">Akihide Ryo</name><name sortKey="Sakamori, Ryotaro" sort="Sakamori, Ryotaro" uniqKey="Sakamori R" first="Ryotaro" last="Sakamori">Ryotaro Sakamori</name><name sortKey="Takehara, Tetsuo" sort="Takehara, Tetsuo" uniqKey="Takehara T" first="Tetsuo" last="Takehara">Tetsuo Takehara</name><name sortKey="Tatsumi, Tomohide" sort="Tatsumi, Tomohide" uniqKey="Tatsumi T" first="Tomohide" last="Tatsumi">Tomohide Tatsumi</name><name sortKey="Watashi, Kohei" sort="Watashi, Kohei" uniqKey="Watashi K" first="Kohei" last="Watashi">Kohei Watashi</name><name sortKey="Yamada, Ryoko" sort="Yamada, Ryoko" uniqKey="Yamada R" first="Ryoko" last="Yamada">Ryoko Yamada</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
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